Efnisyfirlit

• Cover
• Title Page
• Copyright
• ABOUT THE COMPANION WEBSITE
• CHAPTER ONE: The Beginnings of Molecular Biology
  • 1.1 Introduction
  • 1.2 Insights into the nature of the hereditary material
  • 1.3 A model for the structure of DNA: The DNA double helix
  • 1.4 The central dogma of molecular biology
  • 1.5 An evolutionary framework for heredity
  • BIBLIOGRAPHY
• CHAPTER TWO: The Structure of DNA
  • 2.1 Introduction
  • 2.2 Primary structure: the components of nucleic acids
  • 2.3 Secondary structure of DNA
  • 2.4 Unusual DNA secondary structures
  • 2.5 Tertiary structure of DNA
  • BIBLIOGRAPHY
• CHAPTER THREE: The Versatility of RNA
  • 3.1 Introduction
  • 3.2 RNA is involved in a wide range of cellular processes
  • 3.3 Structural motifs of RNA
  • 3.4 The discovery of RNA catalysis
  • 3.5 RNA‐based genomes
  • BIBLIOGRAPHY
• CHAPTER FOUR: Protein Structure and Folding
  • 4.1 Introduction
  • 4.2 Primary structure: amino acids and the genetic code
  • 4.3 The three‐dimensional structure of proteins
  • 4.4 Protein function and regulation of activity
  • 4.5 Protein folding and misfolding
  • BIBLIOGRAPHY
• CHAPTER FIVE: Genome Organization and Evolution
  • 5.1 Introduction
  • 5.2 Genome organization varies in different organisms
  • 5.3 Packaging of the eukaryotic genome
  • 5.4 The majority of the eukaryotic genome is noncoding
  • 5.5 Lateral gene transfer contributes to genome evolution
  • 5.6 Prokaryotic and viral genome organization
  • BIBLIOGRAPHY
• CHAPTER SIX: DNA Replication and Telomere Maintenance
  • 6.1 Introduction
  • 6.2 Early insights into the mode of bacterial DNA replication
  • 6.3 DNA polymerases are the enzymes that catalyze DNA synthesis from 5′ to 3′
  • 6.4 The bacterial replisome
  • 6.5 The eukaryotic replisome
  • 6.6 Alternative modes of circular DNA replication
  • 6.7 Telomere maintenance: the role of telomerase in DNA replication, aging, and cancer
  • BIBLIOGRAPHY
• CHAPTER SEVEN: DNA Repair Pathways
  • 7.1 Introduction
  • 7.2 Mutations and DNA damage
  • 7.3 Lesion bypass
  • 7.4 Direct reversal of DNA damage
  • 7.5 Repair of single base changes and structural distortions by removal of DNA damage
  • 7.6 Double‐strand break repair by removal of DNA damage
  • BIBLIOGRAPHY
• CHAPTER EIGHT: Transcription in Bacteria
  • 8.1 Introduction
  • 8.2 Mechanism of transcription
  • 8.3 Insights into gene regulation from the lactose (lac) operon
  • 8.4 Mode of action of transcriptional regulators
  • 8.5 Control of gene expression by RNA
  • 8.6 Gene regulatory networks
  • BIBLIOGRAPHY
• CHAPTER NINE: Transcription in Eukaryotes
  • 9.1 Introduction
  • 9.2 Overview of transcriptional regulation
  • 9.3 Protein‐coding gene regulatory elements
  • 9.4 The general transcription machinery and mechanism of transcription
  • 9.5 The role of specific transcription factors in gene regulation
  • 9.6 Transcriptional coactivators and corepressors
  • 9.7 Transcription complex assembly: the enhanceosome model versus the “hit‐and‐run” model
  • 9.8 Regulated nuclear import and export of transcription factors
  • BIBLIOGRAPHY
• CHAPTER TEN: Epigenetic Mechanisms of Gene Regulation
  • 10.1 Introduction
  • 10.2 Epigenetic markers
  • 10.3 Genomic imprinting
  • 10.4 X chromosome inactivation
  • 10.5 Epigenetic control of transposable elements
  • 10.6 Epigenetics and nutritional legacy
  • 10.7 Allelic exclusion
  • BIBLIOGRAPHY
• CHAPTER ELEVEN: RNA Processing and Posttranscriptional Gene Regulation
  • 11.1 Introduction
  • 11.2 The discovery of split genes
  • 11.3 Splicing occurs by a variety of mechanisms
  • 11.4 Cotranscriptional processing of nuclear pre‐mRNA
  • 11.5 Alternative splicing
  • 11.6 RNA editing
  • 11.7 Post‐transcriptional gene regulation by RNAi
  • 11.8 RNA turnover in the nucleus and cytoplasm
  • BIBLIOGRAPHY
• CHAPTER TWELVE: The Mechanism of Translation
  • 12.1 Introduction
  • 12.2 Ribosome structure and assembly
  • 12.3 Aminoacyl‐tRNA synthetases
  • 12.4 Initiation of translation
  • 12.5 Elongation and events in the ribosome tunnel
  • 12.6 Termination of translation
  • 12.7 Translational and post‐translational control
  • BIBLIOGRAPHY
• CHAPTER THIRTEEN: Recombinant DNA Technology and Genetically Modified Organisms
  • 13.1 Introduction
  • 13.2 The beginnings of recombinant DNA technology
  • 13.3 Cutting and joining DNA
  • 13.4 Molecular cloning
  • 13.5 Library screening and probes
  • 13.6 Restriction mapping and RFLP analysis
  • 13.7 DNA sequencing
  • 13.8 Introduction to genetically modified organisms
  • 13.9 Transgenic mice: pronuclear microinjection
  • 13.10 Gene targeting in mouse embryonic stem cells
  • 13.11 CRISPR‐Cas gene editing
  • 13.12 Applications of genetically modified animals
  • 13.13 Cloning by nuclear transfer
  • 13.14 Transgenic plants
  • BIBLIOGRAPHY
• CHAPTER FOURTEEN: Tools for Analyzing Gene Organization, Expression, and Function
  • 14.1 Introduction
  • 14.2 DNA typing
  • 14.3 Genomics, proteomics, and beyond
  • 14.4 Whole‐genome sequencing
  • 14.5 Reporter genes
  • 14.6 Transcriptomics: RNA expression and localization
  • 14.7 Proteomics: protein expression and localization
  • 14.8 Analysis of nucleic acid–protein interactions
  • 14.9 Analysis of protein–protein interactions
  • 14.10 Structural analysis of proteins
  • BIBLIOGRAPHY
• CHAPTER FIFTEEN: Medical Molecular Biology
  • 15.1 Introduction
  • 15.2 Genomic medicine
  • 15.3 Molecular biology of cancer
  • 15.4 Gene therapy
  • BIBLIOGRAPHY
• APPENDIX
  • Chapter 1
  • Chapter 2
  • Chapter 3
  • Chapter 4
  • Chapter 5
  • Chapter 6
  • Chapter 7
  • Chapter 8
  • Chapter 9
  • Chapter 10
  • Chapter 11
  • Chapter 12
  • Chapter 13
  • Chapter 14
  • Chapter 15
• GLOSSARY
• Index
• End User License Agreement

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