Clinical Hematology and Fundamentals of Hemostasis
Námskeið LEI301G Blóðmeinafræði - sjúkdómafræði - Höfundur: Denise M Harmening
23.790 kr.
Námskeið
- LEI301G Blóðmeinafræði - sjúkdómafræði
Lýsing:
A full-color text, lab manual, & atlas—all in one! Here are all the tools medical laboratory science students need to master the principles of hematology and the fundamentals of hemostasis. Author Denise M. Harmening has curated contributions from a team of e xpert educators and clinicians. With support from her Associate Editor LeAnne Hutson, she brings you comprehensive, yet focused coverage that prepares you for the real world in which you will practice.
Annað
- Höfundur: Denise Harmening
- Útgáfa:1
- Útgáfudagur: 2024-02-01
- Engar takmarkanir á útprentun
- Engar takmarkanir afritun
- Format:ePub
- ISBN 13: 9781719653138
- Print ISBN: 9780803694439
- ISBN 10: 1719653135
Efnisyfirlit
- Cover
- Title Page
- Copyright Page
- Dedication
- Acknowledgments
- Preface
- Special Collaborators
- Contributors
- Reviewers
- Contents
- Part 1: Introduction to Clinical Hematology
- Chapter 1: Morphology and Maturation of Human Blood Cells: Hematopoiesis
- Basic Morphology and Basic Concepts
- Morphology of Cells on the Normal Blood Smear
- Erythrocytes (Red Blood Cells)
- Platelets (Thrombocytes)
- Leukocytes (White Blood Cells)
- Hematopoiesis
- Description
- Origin of Hematopoiesis
- Erythropoiesis
- Pronormoblast (Rubriblast, Proerythroblast)
- Basophilic Normoblast (Prorubricyte, Basophilic Erythroblast)
- Polychromatophilic Normoblast (Rubricyte, Polychromatophilic Erythroblast)
- Orthochromatic Normoblast (Metarubricyte, Orthochromatic Erythroblast)
- Reticulocyte (Diffusely Basophilic Erythrocyte, Polychromatophilic Erythrocyte)
- Erythrocyte (Red Blood Cell, Discocyte)
- Myelopoiesis (Granulocytopoiesis)
- Morphological Changes
- Stages of Differentiation and Maturation
- Monopoiesis
- Monoblasts and Promonocytes
- Monocytes and Macrophages
- Lymphopoiesis
- Lymphoblasts and Prolymphocytes
- Lymphocytes
- Plasmablasts and Proplasmacytes
- Plasmacytes (Plasma Cells)
- Megakaryocytopoiesis
- Bone-Derived Cells
- Osteoblasts
- Osteoclasts
- Cell Line Ontogeny (Evolution)
- Multipotent Stem Cells—Colony-Forming Units (CFUs) (Hematopoietic Stem Cell)
- Trends in Therapeutic Manipulation of Hematopoiesis
- Recombinant Cytokines
- Clinical Trials of Recombinant Cytokines
- Clusters of Differentiation Nomenclature
- Clinical Applications of Cell Surface Markers
- Chapter 1: Morphology and Maturation of Human Blood Cells: Hematopoiesis
- Chapter 2: The Red Blood Cell: Structure and Function
- The Red Blood Cell Membrane
- Red Blood Cell Membrane Proteins
- Deformability
- Permeability
- Red Blood Cell Membrane Lipids
- Hemoglobin Structure and Function
- Hemoglobin Synthesis
- Hemoglobin Function
- Abnormal Hemoglobins of Clinical Importance
- Maintenance of Hemoglobin Function: Active Red Blood Cell Metabolic Pathways
- Erythrocyte Senescence and Hemolysis
- Extravascular Hemolysis
- Intravascular Hemolysis
- The Red Blood Cell Membrane
- Bone Marrow Structure
- Erythropoiesis
- Granulopoiesis
- Megakaryopoiesis
- Lymphopoiesis
- Stem Cells
- Hematogones
- Marrow Stromal Cells
- Mast Cells
- Bone-Forming Cells
- Bone Marrow Function
- Indications for Bone Marrow Studies
- Obtaining and Preparing Bone Marrow for Hematologic Studies
- Equipment
- Aspiration
- Preparation of Bone Marrow Aspirate
- Histologic Marrow Particle Preparation
- Bone Marrow Core Biopsy
- Preparation of Trephine Biopsy
- Bone Marrow Examination
- Estimation of Bone Marrow Cellularity
- Bone Marrow Differential Count
- Bone Marrow and Peripheral Blood Interpretation Based on Cellularity and M:E Ratio Changes
- Bone Marrow Iron Stores
- Bone Marrow Report
- Automation in the Hematology Laboratory
- Examination of the Peripheral Blood Smear
- Low-Power (10×) Scan
- High-Power (40×) Scan
- Oil Immersion (100×) Examination
- The Normal Red Blood Cell
- Assessment of Red Cell Abnormality
- Variations in Red Cell Distribution
- Normal Distribution
- Abnormal Distribution
- Variations in Red Cell Size
- Anisocytosis
- Normocytes
- Macrocytes
- Microcytes
- Hemoglobin Content—Red Cell Color Variations
- Normochromia
- Hypochromia
- Hyperchromia
- Polychromasia
- Variations in Red Cell Shape
- Poikilocytosis
- Target Cells (Codocytes)
- Spherocytes
- Stomatocytes
- Ovalocytes and Elliptocytes
- Sickle Cells (Drepanocytes)
- Fragmented Cells
- Burr Cells (Echinocytes)
- Acanthocytes (Thorn Cells, Spur Cells)
- Teardrop Cells (Dacrocytes)
- Red Cell Inclusions
- Howell–Jolly Bodies
- Basophilic Stippling
- Pappenheimer Bodies and Siderotic Granules
- Heinz Bodies
- Cabot Rings
- Hemoglobin C Crystals
- Hemoglobin SC Crystals
- Protozoan Inclusions
- Examination of Platelet Morphology
- Examination of White Blood Cell Morphology
- Immature White Blood Cells
- White Blood Cell Morphology
- WBC Cytoplasmic Inclusions
- Quality Management
- Legal Implications
- Quality Management Plans
- Quality Approaches
- Quality System Essentials
- Quality Assurance and Quality Control
- Key Definitions
- General Quality Assurance Control Activity Guidelines
- Preanalytical, Analytical, and Postanalytical Factors in Testing
- Accuracy, Precision, and Error
- Method Validation
- CLIA Minimum Quality Control Requirements
- Levy–Jennings Graphs
- Westgard MultiRule Quality Control
- Peer Group Quality Control
- Hematology Laboratory Applications
- Quality Plan Example
- Method Validation Studies
- Quality Control
- Chapter 6: Anemia: Diagnosis and Clinical Considerations
- Causes, Considerations, and Compensatory Mechanisms
- Clinical Diagnosis of Anemia
- Classification of Anemia
- Laboratory Classification of Anemias
- Hemoglobin and Hematocrit Levels
- Morphological Classification of Anemias
- Other Laboratory Tests
- New RBC Parameters in Testing for Anemia
- Overview of the Treatment of Anemia
- Chapter 7: Iron Metabolism and Hypochromic Anemias
- Normal Iron Metabolism
- Distribution and Requirements
- Daily Iron Requirements
- Sources of Iron
- Iron Absorption and Transport
- Iron Regulation
- Iron Storage
- Laboratory Evaluation
- Serum Iron
- Total Iron-Binding Capacity
- Transferrin Saturation
- Ferritin
- Transferrin Receptor
- Free Erythrocyte Protoporphyrin and Zinc Protoporphyrin
- Bone Marrow Iron
- Reticulocyte Count and Reticulocyte Corpuscular Hemoglobin (CHr)
- Hepcidin
- Iron-Deficiency Anemia
- Etiology
- Pathophysiology
- Clinical Findings
- Laboratory Testing and Results
- Treatment
- Anemia of Chronic Inflammation
- Etiology
- Pathophysiology
- Clinical Findings
- Laboratory Testing and Results
- Treatment
- Sideroblastic Anemia
- Etiology
- Pathophysiology
- Clinical Findings
- Laboratory Testing and Results
- Treatment
- The Porphyrias
- Iron Overload and Hemochromatosis
- Etiology
- Pathophysiology
- Clinical Findings
- Laboratory Testing and Results
- Treatment
- Normal Iron Metabolism
- Etiology: Biochemical Aspects
- Clinical Manifestations
- Hematologic Features
- Ineffective Hematopoiesis
- Bone Marrow Morphology
- Peripheral Blood Morphology
- Etiology: B12 and Folic Acid Deficiency
- Vitamin B12 Deficiency
- Folic Acid Deficiency
- Laboratory Diagnosis of Megaloblastic Anemia
- Laboratory Tests for the Diagnosis of Vitamin B12 and Folic Acid Deficiencies
- Treatment
- Therapy for Vitamin B12 Deficiency
- Therapy for Folic Acid Deficiency
- Response to Therapy
- Macrocytic Nonmegaloblastic Anemias
- Vitamin-Independent Megaloblastic Changes
- Inherited
- Acquired
- Drug and Toxin Induced
- Classification of Hemolytic Anemias
- Approach to Diagnosis of a Hemolytic State
- Tests Reflecting Increased Red Cell Destruction
- Tests Reflecting Increased Red Cell Production
- Establishing the Cause of Hemolysis
- Hereditary Defects of the Red Cell Membrane
- Red Cell Membrane Structure
- Classification of Hereditary Defects of the Red Cell Membrane
- Hereditary Spherocytosis
- Hereditary Elliptocytosis
- Disorders of Red Cell Hydration
- Hereditary Hydrocytosis and Hereditary Xerocytosis
- Enzyme Deficiencies: Hexose Monophosphate Pathway
- Glucose-6-Phosphate Dehydrogenase Deficiency
- Enzyme Deficiencies: Glycolytic Pathway
- Pyruvate Kinase Deficiency (PKD)
- Other Enzyme Deficiencies of the Glycolytic Pathway
- Enzyme Deficiencies: Methemoglobin Reductase Pathway
- Methemoglobin Reductase Deficiency
- Methemoglobinemia
- Review of Normal Hemoglobin Structure
- Overview of the Hemoglobinopathies
- Classification
- Nomenclature
- Laboratory Diagnosis
- Sickle Cell Anemia
- Historic Overview
- Definition
- Pathophysiology
- Clinical Findings
- Sickle Cell Trait
- Laboratory Testing and Results
- Laboratory Screening for Sickle Cell Disease
- Treatment
- Hemoglobin C Disease and Trait
- Hemoglobin D Disease and Trait
- Hemoglobin E Disease and Trait
- Hemoglobin OArab Disease and Trait
- Hemoglobin S With Other Abnormal Hemoglobins
- Hemoglobin SC Disease
- Hemoglobin SD Disease
- Hemoglobin SOArab and S-Oman Disease
- Hemoglobin S/β-Thalassemia Combination
- Laboratory Diagnosis of HbS With Other Abnormal Hemoglobins
- Unstable Hemoglobins
- Methemoglobinemia
- Genetics of Hemoglobin Synthesis
- Pathophysiology
- Thalassemia Syndromes
- A Broad Clinical Classification of Thalassemia Syndromes
- Beta Thalassemia
- Alpha Thalassemia
- Other Thalassemias and Thalassemia-Like Conditions
- Laboratory Diagnosis
- Routine Hematology Procedures
- Flow Cytometry
- Hemoglobin Electrophoresis
- High Performance Liquid Chromatography
- Hemoglobin Quantitation
- Routine Chemistry
- Differential Diagnosis of Microcytic, Hypochromic Anemia
- Treatment
- Blood Transfusion
- Other Treatments
- Curative Treatment
- Prevention
- Aplastic Anemia
- Pathogenesis
- Etiology
- Clinical Findings of Aplastic Anemia
- Laboratory Evaluation of Acquired Aplastic Anemia
- Treatment of Aplastic Anemia
- Congenital Aplastic Anemia
- Pure Red Cell Aplasia
- Acquired Pure Red Cell Aplasia
- Congenital Pure Red Cell Aplasia: Diamond-Blackfan Anemia
- Congenital Dyserythropoietic Anemias
- Paroxysmal Nocturnal Hemoglobinuria
- Pathogenesis
- Clinical Findings
- Laboratory Evaluation
- Treatment
- Relationships Among Conditions of Bone Marrow Hypoplasia
- Immune Hemolytic Anemia
- Immune Hemolysis
- Classification of Immune Hemolytic Anemia
- Nonimmune Hemolytic Anemia
- Intracellular Infections
- Extracellular Infections
- Mechanical Etiologies
- Chemical and Physical Agents
- Acquired Membrane Disorders
- Anemia of Chronic Kidney Disease
- Etiology and Pathophysiology
- Clinical Findings
- Laboratory Evaluation
- Treatment
- Anemia of Liver Disease
- Etiology and Pathophysiology
- Clinical Findings
- Laboratory Evaluation
- Treatment
- Anemia of Endocrine Disease/Disorders
- Diabetes
- Adrenal Insufficiency
- Thyroid Disease
- Hyperparathyroidism
- Hypogonadism
- Pituitary Dysfunction
- Myelophthisic Anemia
- Etiology and Pathophysiology
- Clinical Findings
- Laboratory Evaluation
- Treatment
- Anemia Associated With Viral Infections
- SARS-CoV-2 and COVID-19
- HIV and AIDS
- Anemia of Prematurity
- Etiology and Pathophysiology
- Clinical Findings
- Laboratory Evaluation
- Treatment
- Acknowledgment
- Chapter 16: Benign White Blood Cell Disorders
- Neutrophils
- Neutrophil Function
- Disorders of Neutrophils
- Eosinophils
- Basophils
- Monocytes
- Lymphocytes
- Absolute Lymphocytosis: Reactive Versus Malignant Causes
- Lymphocytopenia
- Neutrophils
- Overview of Leukemia
- Incidence and Prevalence
- Clinical Findings
- Historical Perspectives
- Etiology and Risk Factors
- Acute Leukemia
- Incidence
- Clinical Findings
- Evaluation of Morphology
- Acute Myeloid Leukemia
- FAB Classification
- WHO Classification
- Laboratory Testing of Acute Leukemia
- Specimens
- Cytochemistry
- Immunological Marker Studies
- Flow Cytometry
- Genetic Analysis
- Cytogenetics and FISH
- Molecular Studies
- Six Major Categories of the WHO Classification
- AML With Recurrent Genetic Abnormalities
- AML With Myelodysplasia-Related Changes
- Therapy-Related Myeloid Neoplasms
- Acute Myeloid Leukemia, Not Otherwise Specified
- Myeloid Sarcoma
- Myeloid Proliferations Related to Down Syndrome
- Acute Lymphoblastic Leukemia/Lymphoma (ALL/LBL)
- Review of Lymphocyte Ontogeny
- Clinical Findings
- Morphology
- Historical Classification: FAB Classification of ALL
- World Health Organization Classification of ALL
- T-Lymphoblastic Leukemia/Lymphoma (T-ALL/LBL)
- Burkitt’s Leukemia/Lymphoma (Mature B-CELL ALL)
- Childhood versus Adult ALL
- Acute Leukemias of Ambiguous Lineage
- Acute Leukemia of Ambiguous Lineage, Not Otherwise Specified
- Treatment of Acute Leukemia
- Chronic Myelogenous Leukemia
- Etiology
- Pathogenesis
- Clinical Findings
- Phases
- Laboratory Testing and Results
- Differential Diagnosis
- Prognosis
- Treatment
- Atypical Chronic Myelogenous Leukemia
- Chronic Neutrophilic Leukemia
- Chronic Eosinophilic Leukemia, Not Otherwise Specified
- Myeloproliferative Neoplasms, Unclassifiable
- Overview of Myeloproliferative Neoplasms
- History of the World Health Organization Classification
- Genetic Basis of Classical MPNs
- General Differentiation of MPNs
- Polycythemia Vera
- Definition
- Incidence
- Pathogenesis
- Clinical Findings
- Laboratory Testing and Results
- Differential Diagnosis
- Treatment
- Essential Thrombocythemia
- Definition
- Incidence
- Pathogenesis
- Clinical Findings
- Laboratory Testing and Results
- Differential Diagnosis
- Treatment
- Primary Myelofibrosis
- Definition
- Incidence
- Pathogenesis
- Clinical Findings
- Laboratory Testing and Results
- Differential Diagnosis
- Treatment
- Epidemiology, Etiology, and Pathogenesis
- MDS and Precursor States: Clonal Proliferative Diseases
- Genetic Anomalies
- Biological Characteristics of Disease Progression
- Ineffective Hematopoiesis
- Clinical Findings
- Prognosis
- Morphological Characteristics of Blood and Bone Marrow
- Definitions of Specific Morphological Characteristics
- Lineage Dysplasias
- Classification of MDS Subtypes
- MDS With Single Lineage Dysplasia
- MDS With Multilineage Dysplasia
- MDS With Ring Sideroblasts
- MDS With Isolated del(5q)
- MDS With Excess Blasts
- MDS, Unclassified
- Laboratory Testing and Results
- Bone Marrow Histology
- Flow Cytometry
- Cytogenetic and Molecular Abnormalities
- Therapy-Related Myelodysplastic Syndromes
- Myelodysplastic Syndromes in Children
- Diagnostic Challenges
- Reactive Causes of Dysplasia
- Cytogenetic and Molecular Findings Without Morphological Dysplasia
- MDS With Hypoplastic Marrow
- Treatment
- Supportive Care and Hematopoiesis-Improving Therapies
- Therapies Oriented Toward Improving Survival
- Myelodysplastic/Myeloproliferative Overlap Syndromes
- Overview of Chronic Lymphocytic Leukemia
- Normal B-Cell Development
- Classification of Lymphoid Neoplasms
- Hematologic Abnormalities
- Epidemiology
- Etiology
- Pathophysiology
- Phenotypic Features and Methods for Studying Lymphocytes
- Clinical Findings
- Laboratory Testing and Results
- Genetic Abnormalities and Molecular Pathophysiology
- Clinical Course, Prognostic Factors, and Staging
- Treatment
- Differential Diagnosis
- CLL versus ALL
- B-Prolymphocytic Leukemia
- Small Lymphocytic Lymphoma
- Mantle Cell Lymphoma
- Small Cleaved-Cell Follicular Lymphoma
- Hairy Cell Leukemia
- Sézary Syndrome
- Adult T-Cell Leukemia/Lymphoma
- Chronic T-Cell Large Granular Lymphocytic Leukemia
- Reactive (Atypical) Lymphocytosis
- Plasma Cell Dyscrasias
- Hodgkin Lymphoma
- Epidemiology, Etiology, and Pathogenesis
- Pathology
- Clinical Findings
- Staging and Treatment
- Non-Hodgkin Lymphoma
- Epidemiology, Etiology, and Pathogenesis
- Pathology
- B-Cell Lymphomas
- T-Cell and Natural Killer (NK)-Cell Lymphomas
- Histiocytic and Dendritic Cell Tumors
- Diagnostic Evaluation of Lymphoid Neoplasia
- Treatment and Prognosis
- Acknowledgment
- Plasma Cell Development
- Immunoglobulin
- Structure and Function
- Abnormal Monoclonal Immunoglobulin Level Recognition and Measurement
- Laboratory Recognition and Measurement
- Monoclonal Gammopathy of Undetermined Significance
- Smoldering Myeloma
- Multiple Myeloma
- Epidemiology
- Etiology
- Pathophysiology
- Clinical Findings
- Laboratory Testing and Results
- Diagnostic Criteria
- Staging
- Treatment
- Variants of Plasma Cell Syndromes
- Solitary Plasmacytoma
- Plasma Cell Leukemia
- Nonsecretory Myeloma
- POEMS Syndrome
- Waldenström Macroglobulinemia
- Light-Chain Amyloidosis
- Light-Chain Deposition and Heavy-Chain Diseases
- Overview of Lipid Storage Diseases
- Gaucher’s Disease
- Historical Perspective
- Classification and Clinical Findings
- Laboratory Testing and Results
- Prognosis
- Treatment
- Niemann–Pick Disease
- Classification and Clinical Findings
- Laboratory Testing and Results
- Prognosis and Treatment
- Tay–Sachs Disease
- Clinical Findings
- Laboratory Testing and Results
- Prognosis and Treatment
- Mucopolysaccharidoses
- Classification
- Clinical Findings
- Laboratory Testing and Results
- Prognosis and Treatment
- Histiocytosis
- Sea-Blue Histiocyte Syndrome
- Langerhans Cell Histiocytosis
- Chapter 25: Hemostasis
- Platelets and the Hemostatic Mechanisms
- Stages of Hemostasis
- Vascular System
- Primary Hemostasis
- Platelet Structure
- Platelet Function and Platelet Plug Formation
- Secondary Hemostasis: Fibrin-Forming (Coagulation) System
- Classification of Coagulation Factors by Hemostatic Function
- Classification of Coagulation Factors by Physical Properties
- Blood Coagulation: The “Cascade” Theory
- Extrinsic Pathway (Factor VII)
- Intrinsic Pathway (Factors XII, XI, IX, and VIII)
- Common Pathway (Factors X, V, II, and I)
- Thrombin-Mediated Reactions in Hemostasis
- Thrombin-Mediated Platelet Aggregation
- Thrombin Formation: Role of Extrinsic Pathway
- Thrombin Formation: Role of Common Pathway
- Thrombin-Mediated Anticoagulant Activity
- Thrombin-Mediated Tissue Repair
- Fibrin-Lysing (Fibrinolytic) System
- Kinin System
- Complement System
- Laboratory Evaluation of Hemostasis
- Platelets and the Hemostatic Mechanisms
- Chapter 26: Disorders of Primary Hemostasis: Quantitative and Qualitative Platelet Disorders and Vascular Disorders
- Laboratory Evaluation of Disorders of Primary Hemostasis
- Quantitative Platelet Disorders: Thrombocytopenia
- Deficient Platelet Production
- Abnormal Distribution of Platelets
- Increased Destruction of Platelets
- Quantitative Platelet Disorders: Thrombocytosis
- Primary Thrombocytosis
- Reactive Thrombocytosis
- Qualitative Platelet Disorders
- Congenital Disorders of Platelet Function
- Acquired Qualitative Platelet Disorders
- Vascular Disorders
- Primary Purpura
- Secondary Purpura
- Vascular and Connective Tissue Disorders
- Plasma Clotting Factors, Associated Disorders, Laboratory Evaluation, and Treatment
- Fibrinogen (Factor I)
- Factor II (Prothrombin)
- Factor V (Proaccelerin; Labile Factor)
- Factor VII (Proconvertin; Stable Factor)
- Factor VIII (Antihemophilic Factor) and von Willebrand Factor
- Factor IX (Christmas Factor; Plasma Thromboplastin Component [PTC])
- Factor X (Stuart–Prower Factor)
- Factor XI (Plasma Thromboplastin Antecedent [PTA])
- Factor XII (Hageman Factor)
- Factor XIII (Fibrin-Stabilizing Factor)
- Prekallikrein (Fletcher Factor)
- High Molecular Weight Kininogen (Fitzgerald Factor; Flaujeac Factor; Williams–Fitzgerald–Flaujeac Factor)
- Circulating Anticoagulants/Acquired Inhibitors
- Specific Inhibitors
- Nonspecific Inhibitors: The Lupus Anticoagulant and Antiphospholipid Antibodies
- Components of the Fibrinolytic System
- Plasminogen
- Plasminogen Activators
- Plasminogen Activator Inhibitor-1
- Plasmin
- α2-Antiplasmin
- Thrombomodulin
- Thrombin-Activatable Fibrinolysis Inhibitor
- Fibrin and Fibrinogen
- Congenital Abnormalities of the Fibrinolytic System
- Disseminated Intravascular Coagulation
- Triggering Mechanisms and Associated Clinical Disorders
- Clinical Presentation
- Laboratory Diagnosis
- Treatment
- Related Disorders
- History
- Regulation of Coagulation and Fibrinolysis
- Role of Endothelium
- Platelets
- Procoagulant Factors and Thrombin Generation
- Natural Inhibitors of Coagulation Factors (Plasma Components)
- Fibrinolytic System
- Inherited Thrombophilia
- Activated Protein C Resistance
- Protein C Deficiency
- Protein S Deficiency
- Antithrombin Deficiency
- Prothrombin (F2) G20210A Mutation
- Hyperhomocysteinemia
- Tissue Factor Pathway Inhibitor Deficiency
- Factor XII Deficiency
- Dysfibrinogenemia
- Elevated Plasma Factor VIII Coagulant Activity
- Lipoprotein a and Thrombosis
- Other Coagulant Factors Associated With Thrombosis
- Acquired Thrombotic Disorders
- Lupus Anticoagulant/Antiphospholipid Syndrome
- Heparin-Induced Thrombocytopenia
- Other Acquired Conditions Associated With Thrombosis
- Thrombosis With Pregnancy and Use of Oral Contraceptives
- Thrombosis and Nephrotic Syndrome
- Cancer-Associated Thrombosis (CAT)
- Diagnostic Approach and Issues in Laboratory Testing
- Complete History and Physical Examination
- Conditions That Can Interfere With Test Results
- Testing in the Appropriate Clinical Setting
- Functional Assays
- Anticoagulant Therapy
- Unfractionated Heparin Therapy
- Low Molecular Weight Heparin
- Vitamin K Antagonists
- Direct Oral Anticoagulants (DOACs)
- Antiplatelet Agents
- Thrombolytic Therapy
- Chapter 30: Body Fluid Examination: Analysis of Serous, Cerebrospinal, and Synovial Fluids
- Types of Body Fluids and Anatomy
- Serous Fluids: Pericardial, Pleural, and Peritoneal
- Cerebrospinal Fluid
- Synovial Fluid
- Specimen Collection and Preparation
- Collection
- Preparation
- Laboratory Analysis and Clinical Correlations
- Cellular Components of Body Fluids
- Neutrophils
- Lymphocytes
- Macrophages
- Tissue Cells
- Eosinophils, Basophils, and Mast Cells
- Serous Fluids: Pleural, Pericardial, and Peritoneal
- Effusions: Transudates and Exudates
- Cellular Responses, Microorganisms, and Malignant Cells
- Types of Effusions, Laboratory Analysis, and Clinical Correlations
- Pleural and Pericardial Effusions
- Peritoneal Effusions
- Cerebrospinal Fluid (CSF)
- Specimen Collection and Processing
- Laboratory Analysis and Clinical Correlations
- Synovial Fluid
- Specimen Collection and Processing
- Laboratory Analysis and Clinical Correlations
- Crystal Analysis and Clinical Correlations
- Artifacts
- Acknowledgments
- Types of Body Fluids and Anatomy
- Chapter 31: Hematology Methods
- Analytical Phases of Testing
- Specimen Collection
- Patient Identification
- Safety
- Verification of Laboratory Orders
- Method 31–1. Venipuncture
- Method 31–2. Capillary Blood Collection
- Labeling the Blood Specimen
- Specimen Accessioning
- Manual Cell Counts
- Method 31–3. Red Blood Cell Counts
- Method 31–4. White Blood Cell Counts
- Method 31–5. Platelet Counts
- Evaluation of the Peripheral Blood Smear
- Method 31–6. Slide Preparation and Wright Stain
- Alternate Staining Options
- Method 31–7. The White Blood Cell Differential
- Methods Used in Detection and Monitoring of Anemia
- Method 31–8. Hemoglobin Determination
- Method 31–9. Microhematocrit Determination
- Method 31–10. Red Blood Cell Indices
- Method 31–11. Reticulocyte Counts
- Method 31–11A. Reticulocyte Counts Using the Miller Disc
- Standard Methods for Specific Anemias
- Method 31–12. SickledexTM (aka sickle solubility testing)
- Method 31–13. Helena SPIFE® Alkaline Hemoglobin Electrophoresis
- Method 31–14. Helena SPIFE® Acid Hemoglobin Electrophoresis
- Method 31–15. Hemoglobin A2 Determination
- Method 31–16. Isoelectric Focusing
- Method 31–17. Hemoglobin F Acid Stain (Modified Kliehauer-Betke Test)
- Method 31–18. Screening Test for Glucose-6-Phosphate Dehydrogenase Deficiency
- Method 31–19. Staining for Heinz Bodies
- Method 31–20. Screening Method for Detection of Red Cell Pyruvate Kinase
- Nonspecific Tests of Inflammation
- Method 31–21. Westergren Erythrocyte Sedimentation Rate
- Method 31–22. Alifax® Erythrocyte Sedimentation Rate Analyzer
- Specimen Evaluation by Cell Volume and VCS Technology: DxH Analyzer Series, Beckman Coulter®
- Red Cell Analysis
- Platelet Analysis
- Leukocyte Analysis
- Reticulocyte Analysis
- Nucleated Red Blood Cell Detection
- Abnormal Flags
- Body Fluid Analysis
- Additional Parameters
- Specimen Evaluation by Light Scattering and Cytochemical Analysis: ADVIA® Hematology Systems, Siemens Healthcare Diagnostics
- Red Cell Analysis
- Platelet Analysis
- Leukocyte Analysis
- Reticulocyte Analysis
- Nucleated Red Blood Cell Detection
- Abnormal Flags
- Cerebrospinal Fluid Analysis
- Specimen Evaluation With Hydrodynamic Focusing, RF/DC Technology, and Fluorescent Flow Cytometry: The Sysmex XN and XN-L Series Hematology Analyzers
- Red Cell Analysis
- Platelet Analysis
- Leukocyte Analysis
- Reticulocyte Analysis
- Nucleated Red Blood Cell Detection
- Abnormal Flags
- Body Fluid Analysis
- Specimen Evaluation by Multi-Angle Polarized Scatter (MAPSSTM) Technology: Abbott Alinity h-Series
- Red Cell Analysis
- Platelet Analysis
- Leukocyte Analysis
- Reticulocyte Analysis
- Nucleated Red Blood Cell Detection
- Abnormal Flags
- Body Fluid Analysis
- Additional Parameters
- Digital Morphology Analyzers: CellaVision Systems
- Quality Control and Quality Assurance Measures for Automated Complete Blood Count Instruments
- Quality Control Procedures
- Quality Assurance Measures
- Result Verification and Decision Rules
- Acknowledgments
- Platelet Function Instrumentation and Tests
- Method 33–1: Bleeding Time
- Method 33–2: Closure Time—PFA-100® (Siemens)
- Method 33–3: Platelet Aggregation
- Coagulation Instrumentation
- General Types of Coagulation Instrumentation
- Methods of Endpoint Detection
- Complete Hemostasis Assessment
- Coagulation Screening Tests
- Method 33–4: Activated Partial Thromboplastin Time
- Method 33–5: One-Stage Prothrombin Time (Quick)
- Method 33–6: Thrombin Time
- Method 33–7: Mixing Studies—aPTT or PT 1:1: Mix
- Coagulation Factor Assays
- Method 33–8: One-Stage Quantitative Assay Method for Factors II, V, VII, and X
- Method 33–9: One-State Quantitative Assay Method for Factors VIII, IX, XI, and XII
- Method 33–10: Factor XIII Chromogenic Assay (Activity)
- Coagulation Inhibitors
- Tests to Monitor Anticoagulant Therapy
- Monitoring Anticoagulant Therapy With Coagulation Screening Assays
- Method 33–11: Anti-FXa Assay (Heparin Activity)
- Monitoring Direct Thrombin Inhibitors
- Tests to Measure Fibrin Formation
- Method 33–12: Reptilase Time
- Method 33–13: Fibrinogen Activity
- Tests for von Willebrand Disease
- Method 33–14: von Willebrand Factor Antigen
- Method 33–15: von Willebrand Factor Activity (vWF:RCo, Ristocetin Cofactor)
- von Willebrand Collagen Binding Activity
- von Willebrand Factor Multimer Analysis
- Molecular Analysis in vWD
- Tests to Assess Hereditary Thrombotic Risk
- Method 33–16: Activated Protein C Resistance/Factor V Leiden
- Antithrombin Assays
- Method 33–17: Antithrombin Functional Assay (Activity)— Chromogenic Substrate Assay
- Method 33–18: Antithrombin Immunological Assay (Antigen)—Microlatex Particle Immunological Assay
- Protein C Assays
- Method 33–19: Protein C Immunological Assay (Antigen)
- Method 33–20: Protein C Functional Assays (Activity)—Chromogenic Substrate Assay
- Method 33–21: Protein C Clot-Based Assay
- Protein S Assays
- Method 33–22: Protein S Functional Assay (Activity)— Clotting Assay
- Protein S Immunological Assay (Antigen)
- Prothrombin G20210A (Factor II) Mutation
- Tests for the Evaluation of Lupus Anticoagulants
- Confirmatory Tests for Lupus Anticoagulants
- Method 33–23: Platelet Neutralization Procedure
- Hexagonal Phospholipid Neutralization Assay
- Anti-Phospholipid Antibody Assays
- Tests for Fibrinolysis
- D-Dimer Quantitative Test
- Method 33–24: Euglobulin Lysis Time
- Method 33–25: Fibrin Degradation Products: Latex Aggulination Method
- Markers of Coagulation Activation and Thrombin Generation
- Basic Concepts of Flow Cytometry
- Threshold
- Photodetectors
- Amplification
- Fluorescence Compensation
- Flow Cytometric Analysis
- Sample Preparation
- Cytometer Operation
- Data Analysis
- Applications of Flow Cytometry
- Lymphocyte Subset Analysis and CD4 T-Cell Enumeration
- Leukemia and Lymphoma Immunophenotyping
- Leukemia and Lymphoma DNA Content Analysis
- Hematopoietic Progenitor Cell Enumeration
- Flow Crossmatching
- Detection of Paroxysmal Nocturnal Hemoglobinuria
- Residual White Blood Cell Enumeration
- Detection of Fetomaternal Hemorrhage
- Bead-Based Assays for Soluble Factors
- Structure of DNA and RNA
- Applications of DNA Technology in Laboratory Medicine
- Sample Sources for Molecular Procedures
- Nucleic Acid Extraction
- DNA Extraction From Cells or Tissue
- RNA Extraction
- Nucleic Acid Qualification
- Sequence-Specific DNA Fragmentation by Restriction Endonucleases
- Molecular Procedures
- Polymerase Chain Reaction (PCR)
- Reverse Transcription Polymerase Chain Reaction (RT-PCR)
- In Situ Hybridization to Tissue Immobilized on Glass Slides
- Fluorescence In Situ Hybridization
- DNA Sequencing
- Future Prospects of Molecular Assays
UM RAFBÆKUR Á HEIMKAUP.IS
Bókahillan þín er þitt svæði og þar eru bækurnar þínar geymdar. Þú kemst í bókahilluna þína hvar og hvenær sem er í tölvu eða snjalltæki. Einfalt og þægilegt!Rafbók til eignar
Rafbók til eignar þarf að hlaða niður á þau tæki sem þú vilt nota innan eins árs frá því bókin er keypt.
Þú kemst í bækurnar hvar sem er
Þú getur nálgast allar raf(skóla)bækurnar þínar á einu augabragði, hvar og hvenær sem er í bókahillunni þinni. Engin taska, enginn kyndill og ekkert vesen (hvað þá yfirvigt).
Auðvelt að fletta og leita
Þú getur flakkað milli síðna og kafla eins og þér hentar best og farið beint í ákveðna kafla úr efnisyfirlitinu. Í leitinni finnur þú orð, kafla eða síður í einum smelli.
Glósur og yfirstrikanir
Þú getur auðkennt textabrot með mismunandi litum og skrifað glósur að vild í rafbókina. Þú getur jafnvel séð glósur og yfirstrikanir hjá bekkjarsystkinum og kennara ef þeir leyfa það. Allt á einum stað.
Hvað viltu sjá? / Þú ræður hvernig síðan lítur út
Þú lagar síðuna að þínum þörfum. Stækkaðu eða minnkaðu myndir og texta með multi-level zoom til að sjá síðuna eins og þér hentar best í þínu námi.
Fleiri góðir kostir
- Þú getur prentað síður úr bókinni (innan þeirra marka sem útgefandinn setur)
- Möguleiki á tengingu við annað stafrænt og gagnvirkt efni, svo sem myndbönd eða spurningar úr efninu
- Auðvelt að afrita og líma efni/texta fyrir t.d. heimaverkefni eða ritgerðir
- Styður tækni sem hjálpar nemendum með sjón- eða heyrnarskerðingu
- Gerð : 208
- Höfundur : 19012
- Útgáfuár : 2024
- Leyfi : 380
