Efnisyfirlit

• Instructions for online access
• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• Preface
• 1. Introduction to the Immune System: Nomenclature, General Properties, and Components
  • Infections and Immunity
  • Immunologic Disorders
  • Stages of Host Defense: Innate and Adaptive Immunity
  • Properties of Adaptive Immune Responses
  • Cells of the Adaptive Immune System
  • Tissues of the Immune System
  • Summary
• 2. Unlabeled image.Innate Immunity: The Early Defense Against Infections
  • General Features and Specificity of Innate Immune Responses
  • Cellular Receptors for Microbes and Damaged Cells
  • Components of Innate Immunity
  • Innate Immune Reactions
  • Role of Innate Immunity in Stimulating Adaptive Immune Responses
  • Summary
• 3. Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules: What T Lymphocytes See
  • Antigens Recognized by T Lymphocytes
  • Capture of Protein Antigens by Antigen-Presenting Cells
  • Structure and Function of Major Histocompatibility Complex Molecules
  • Processing and Presentation of Protein Antigens
  • Functions of Antigen-Presenting Cells in Addition to Antigen Display
  • Antigen Recognition by Other T Lymphocytes
  • Summary
• 4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires
  • Antigen Receptors of Lymphocytes
  • Development of B and T Lymphocytes
  • Summary
• 5. T Cell–Mediated Immunity: Activation of T Lymphocytes
  • Steps in T Cell Responses
  • Antigen Recognition and Costimulation
  • Biochemical Pathways of T Cell Activation
  • Functional Responses of T Lymphocytes to Antigen and Costimulation
  • Regulation of T Cell Responses by Inhibitory Receptors (Coinhibitors)
  • Migration of T Lymphocytes in Cell-Mediated Immune Reactions
  • Decline of the Immune Response
  • Summary
• 6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense
  • Types of T Cell–Mediated Immune Reactions
  • Development and Functions of CD4+ Effector T Lymphocytes
  • Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes
  • Resistance of Pathogenic Microbes to Cell-Mediated Immunity
  • Summary
• 7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies
  • Phases and Types of Humoral Immune Responses
  • Stimulation of B Lymphocytes by Antigen
  • Functions of Helper T Lymphocytes in Humoral Immune Responses
  • Antibody Responses to T-Independent Antigens
  • Regulation of Humoral Immune Responses
  • Summary
• 8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins
  • Properties of Antibodies That Determine Effector Functions
  • Neutralization of Microbes and Microbial Toxins
  • Opsonization and Phagocytosis
  • Antibody-Dependent Cellular Cytotoxicity
  • Immunoglobulin E– and Mast Cell–Mediated Reactions
  • The Complement System
  • Functions of Antibodies at Special Anatomic Sites
  • Evasion of Humoral Immunity by Microbes
  • Vaccination
  • Summary
• 9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure
  • Immunologic Tolerance: General Priniciples and Significance
  • Central T Lymphocyte Tolerance
  • Peripheral T Lymphocyte Tolerance
  • B Lymphocyte Tolerance
  • Tolerance to Commensal Microbes and Fetal Antigens
  • Autoimmunity
  • Summary
• 10. Tumor and Transplantation Immunology: Immune Responses to Cancer Cells and Normal Foreign Cells
  • Immune Responses Against Tumors
  • Immune Responses Against Transplants
  • Summary
• 11. Hypersensitivity: Disorders Caused by Immune Responses
  • Types of Hypersensitivity Reactions
  • Immediate Hypersensitivity
  • Diseases Caused by Antibodies Specific for Cell and Tissue Antigens
  • Diseases Caused by Antigen-Antibody Complexes
  • Diseases Caused by T Lymphocytes
  • Summary
• 12. Immunodeficiency Diseases: Disorders Caused by Defective Immunity
  • Primary (Congenital) Immunodeficiencies
  • Acquired (Secondary) Immunodeficiencies
  • Acquired Immunodeficiency Syndrome (AIDS)
  • Summary
• Appendix I. Principal Features of Selected CD Molecules
• Appendix II. Cytokines
• Appendix III. Clinical Cases
• Answers to Review Questions
• Index

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